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estimates of prevalence range from 9 34% of patients with shingles

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Induction of shear stress by exposure to fluid movement decreased apoptosis, enhanced proliferation, and the mobility of endothelial cells in these models but did not alter the expression of TJ proteins or P-gp (DeStefano et al., in vivo levels after ~12 days, and integrity is maintained over 3 weeks in culture

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These findings have led to the postulation that deregulated claudin expression helps to promote mucosal inflammation